Player Draft
| Name | State | School | Class | Pos. | Year | Round | Team |
| Jake Ruder | MO | Nixa | 2015 | 1B | 2015 | 37 | Royals |
| Brock Rudy | CA | Northgate | 2019 | C | 2019 | 39th | Astros |
| Will Rudy | CA | Woodbridge | 2019 | SS | 2022 | 5 | Brewers |
| Noah Ruen | TX | Leander | 2021 | RHP | 2023 | 12 | Dodgers |
| John Ruettiger | IL | Joliet Catholic | 2008 | OF | 2011 | 8 | Orioles |
| Luis Rujano | FL | Sunshine State Elite Academy | 2022 | RHP | 2022 | 13 | Cubs |
| T.J. Rumfield | TX | Temple | 2018 | 3B | 2021 | 12 | Phillies |
| Matt Ruppenthal | MI | Brother Rice | 2014 | RHP | 2017 | 17 | Astros |
| Milo Rushford | AZ | Walden Grove | 2022 | OF | 2022 | 18 | Royals |
| Dalton Rushing | TN | Brighton | 2019 | C | 2022 | 2 | Dodgers |
| Ashe Russell | IN | Cathedral | 2015 | RHP | 2015 | 1 | Royals |
| Matt Russell | MO | Staley | 2017 | RHP | 2017 | 40 | Angels |
| Stone Russell | FL | IMG Academy | 2023 | SS | 2023 | 18 | Royals |
| Zane Russell | TX | Porter | 2019 | RHP | 2023 | 10 | Diamondbacks |
| Mason Russell | AZ | Casteel | 2024 | LHP | 2024 | 20 | Reds |
| Luke Russo | MI | Howell | 2019 | RHP | 2023 | 16 | Phillies |
| Carter Rustad | MO | Staley | 2019 | RHP | 2024 | 15 | Orioles |
| Hunter Ruth | FL | Buchholz | 2017 | RHP | 2017 | 32 | Cubs |
| Zach Rutherford | VA | Western Branch | 2014 | SS | 2017 | 6 | Rays |
| Harry Rutkowski | NJ | Woodbridge | 2017 | RHP | 2017 | 28 | Cincinatti Reds |
| Jackson Rutledge | MO | Rockwood Summit | 2017 | RHP | 2019 | 1 | Nationals |
| Zac Ryan | IN | Andrean | 2013 | RHP | 2017 | 23 | Angels |
| Connor Ryan | IL | Lockport | 2013 | RHP | 2017 | 8 | Reds |
| Sam Ryan | VA | Fairfax | 2016 | RHP | 2019 | 12th | Blue Jays |
| Storm Rynard | MO | Raymore-Peculiar | 2014 | RHP | 2014 | 34 | Rangers |
| Eddie Rynders | WI | Wisconsin Lutheran | 2024 | SS | 2024 | 4 | Pirates |
| Andrew Saalfrank | IN | Heritage | 2016 | LHP | 2019 | 6 | DIamondbacks |
| Aaron Sabato | CT | Brunswick School | 2018 | 1B | 2020 | 1 | Minnesota Twins |
| Liam Sabino | PA | Blair Academy | 2014 | SS | 2018 | 35 | Cardinals |
| Tommy Sacco | AZ | Perry | 2017 | SS | 2022 | 14 | Astros |
| Connor Sadzeck | IL | Crystal Lake Central | 2010 | RHP | 2011 | 11 | Rangers |
| Thomas Saggese | CA | Carlsbad | 2020 | SS | 2020 | 5 | Texas |
| Derek Salata | IL | Nazareth | 2018 | RHP | 2023 | 19 | Athletics |
| Antonio Saldana | IL | Joliet Catholic | 2017 | LHP | 2017 | 38 | Giants |
| RJ Sales | NC | Pinecrest | 2021 | RHP | 2024 | 10 | Tigers |
| Bryant Salgado | TX | Klein Forest | 2018 | RHP | 2019 | 34th | San Diego Padres |
| Iziah Salinas | KS | Garden City | 2023 | LHP | 2024 | 17 | Orioles |
| Kyle Salley | IL | Homewood-Flossmoor | 2018 | LHP | 2018 | 40 | White Sox |
| Caleb Sampen | IN | Brownsburg | 2015 | SS | 2018 | 20 | Dodgers |
| Romeo Sanabria | FL | Miami Killian Senior | 2020 | C | 2022 | 18 | Padres |
| Taylor Sanagorski | KS | Bishop Carroll | 2014 | C | 2014 | 39 | Tigers |
| Nolan Sanburn | IN | Kokomo | 2010 | RHP | 2012 | 2 | Athletics |
| Chandler Sanburn | IN | Avon | 2014 | RHP | 2018 | 9 | Rangers |
| Joe Sanchez | FL | Terra Environmental Research Institute | 2017 | LHP | 2017 | 39 | Braves |
| Justin Sanchez | NY | Monsignor McClancy | 2022 | LHP | 2022 | 18 | Rangers |
| Cameron Sanders | LA | E.D. White | 2015 | RHP | 2018 | 12th | Cubs |
| Will Sanders | GA | Woodward Academy | 2020 | RHP | 2023 | 4 | Cubs |
| Travis Sanders | TX | Copperas Cove | 2022 | SS | 2022 | 14 | Red Sox |
| David Sandlin | OK | Owasso | 2019 | RHP | 2022 | 11 | Royals |
| Jayvien Sandridge | PA | Mercersburg Academy | 2018 | LHP | 2018 | 32 | Orioles |
| Wyatt Sanford | TX | Independence | 2024 | SS | 2024 | 2 | Pirates |
| John Sansone | PA | Neshannock | 2012 | SS | 2016 | 8 | Reds |
| Tony SantaMaria | NJ | ACIT | 2020 | SS | 2024 | 19 | Rays |
| Christian Santana | FL | American Heritage | 2017 | RHP | 2017 | 15 | Brewers |
| Andres Santana | FL | Doral Academy Charter | 2017 | OF | 2017 | 29 | Astros |
| Adrian Santana | FL | Doral Academy | 2023 | SS | 2023 | 1-A | Rays |
| Benito Santiago | FL | Coral Springs Christian Academy | 2014 | C | 2014 | 38 | Giants |
| Chris Santiago | CA | De La Salle | 2019 | 3B | 2022 | 18 | Mets |
| Alex Santos | NY | Mount St. Michael Academy | 2020 | RHP | 2020 | 2 | Houston Astros |
| Nolan Santos | FL | Miami Beach | 2019 | RHP | 2023 | 7 | Twins |
| Jonathan Santucci | MA | Phillips Academy Andover | 2021 | LHP | 2024 | 2 | Mets |
| Jamie Sara | VA | West Potomac | 2016 | RHP | 2019 | 25th | Phillies |
| Casey Saucke II | NY | Greece Athena | 2021 | OF | 2024 | 4 | White Sox |
| Kelena Sauer | HI | Kamehameha | 2020 | RHP | 2023 | 15 | Blue Jays |
| Eli Saul | BC | Prince of Wales | 2019 | RHP | 2022 | 13 | Diamondbacks |
| Grayson Saunier | TN | Collierville | 2022 | RHP | 2022 | 19 | Rangers |
| Jason Savacool | NY | Baldwinsville | 2020 | RHP | 2023 | 6 | Cardinals |
| Jon Savarise | IL | Stevenson | 2012 | LHP | 2012 | 33 | White Sox |
| Dan Savas | IL | Leyden | 2010 | RHP | 2014 | 19 | Diamondbacks |
| Nate Savino | VA | Potomac Falls | 2020 | LHP | 2022 | 3 | Diamondbacks |
| Alec Sayre | OH | Dover | 2019 | OF | 2022 | 17 | Twins |
| Nate Scantlin | KS | Rose Hill | 2017 | OF | 0 | 15 | Reds |
| Caden Scarborough | FL | Harmony | 2023 | RHP | 2023 | 6 | Texas Rangers |
| Brandon Schaeffer | PA | Schuylkill Haven | 2018 | LHP | 2022 | 18 | Mariners |
| Reid Schaller | IN | Lebanon | 2016 | RHP | 2018 | 3 | Nationals |
| Brady Schanuel | IL | Belleville East | 2015 | RHP | 2017 | 20 | Phillies |
| Nolan Schanuel | FL | Park Vista | 2020 | OF | 2023 | 1 | Angels |
| Zach Schellenger | PA | Devon Prep | 2014 | RHP | 2017 | 6 | Red Sox |
| Jason Schiavone | VA | St. John's College | 2021 | C | 2024 | 11 | Astros |
| Ethan Schiefelbein | CA | Corona | 2024 | LHP | 2024 | CB-B | Tigers |
| Ryan Schiefer | AZ | Campo Verde | 2021 | RHP | 2024 | 14 | Rays |
| Garrett Schilling | MI | Bishop Foley | 2014 | RHP | 2017 | 18 | Rockies |
| Luke Schiltz | FL | Stoneman Douglas | 2019 | RHP | 2019 | 24th | Texas Rangers |
| Dylan Schlaegel | TX | Mansfield Legacy | 2023 | OF | 2023 | 17 | Red Sox |
| Tyler Schlaffer | IL | Homewood-Flossmoor | 2019 | RHP | 2019 | 9 | Cubs |
| Garrett Schlecht | IL | Waterloo | 2011 | LHP | 2011 | 9 | Cubs |
| Jacob Schlesener | MO | Logan-Rogersville | 2015 | LHP | 2015 | 12 | Cardinals |
| Rafe Schlesinger | NY | Sachem East | 2021 | LHP | 2024 | 4 | Guardians |
| Cam Schlittler | MA | Walpole | 2019 | RHP | 2022 | 7 | Yankees |
| Ryan Schlosser | MN | South St. Paul | 2014 | RHP | 2016 | 32 | Braves |
| Matt Schmidt | CO | Regis Jesuit | 2015 | 3B | 2015 | 37 | Yankees |
| Davis Schneider | NJ | Eastern Regional | 2017 | 3B | 2017 | 28 | Toronto Blue Jays |
| Nicholas Schnell | IN | Roncalli | 2018 | OF | 2018 | 1 | Rays |
| Aaron Schnurbush | MO | Eureka | 2012 | LHP | 2016 | 28 | White Sox |
| Tanner Schobel | VA | Walsingham Academy | 2020 | SS | 2022 | CBB | Twins |
| Garrett Schoenle | IN | Northrop | 2017 | LHP | 2021 | Free Agent | White Sox |
| Cole Schoenwetter | CA | San Marcos | 2023 | RHP | 2023 | 4 | Reds |
| Tyler Schoff | NY | Rome Free Academy | 2017 | RHP | 2021 | Free Agent | Washington Nationals |
| Tyrell (TJ) Schofield-Sam | ON | North Park | 2019 | 3B | 2019 | 12 | Oakland Athletics |
| Jake Schrand | OH | Colerain | 2017 | RHP | 2021 | 9 | Miami Marlins |