Player Draft
| Name | State | School | Class | Pos. | Year | Round | Team |
| Nehomar Ochoa Acosta | TX | Galena Park | 2023 | OF | 2023 | 11 | Astros |
| Nathan Ocker | PA | Middletown Area | 2015 | RHP | 2019 | 29 | Cleveland Indians |
| Josh Ockimey | PA | Neumann-Goretti | 2014 | 1B | 2014 | 5 | Red Sox |
| Jacob Odle | CA | St. Augustine | 2021 | RHP | 2023 | 14 | Cardinals |
| Trennor ODonnell | TX | Faith Christian | 2019 | RHP | 2023 | 8 | Red Sox |
| Jake Odorizzi | IL | Highland | 2008 | RHP | 2008 | 1 | Brewers |
| Keshawn Ogans | CA | Sacred Heart Cathedral | 2019 | OF | 2022 | 20 | Braves |
| Braeden Ogle | FL | Jensen Beach | 2016 | LHP | 2016 | 4 | Pirates |
| Ryne Ogren | PA | Conestoga | 2015 | SS | 2018 | 12 | Mariners |
| Damon Olds | IN | Terre Haute South | 2013 | - | 2017 | 33 | Royals |
| Peyton Olejnik | IN | Hanover Central | 2021 | RHP | 2024 | 6 | Angels |
| Chris Oliver | AR | Shiloh Christian | 2011 | RHP | 2011 | 27 | Orioles |
| Connor Oliver | IL | Oak Forest | 2019 | LHP | 2023 | 17 | Kansas City Royals |
| Michael Oliveto | NY | Hauppauge | 2025 | C | 2025 | CB-A | Detroit Tigers |
| Christian Olivo Ramirez | PR | LCA | 2021 | SS | 2021 | 17 | Cubs |
| Johnny Olmstead | CA | Newport Harbor | 2019 | SS | 2023 | 19 | Marlins |
| Emmett Olson | IL | Maine West | 2020 | LHP | 2023 | 4 | Marlins |
| Reese Olson | GA | North Hall | 2018 | RHP | 2018 | 13th | Brewers |
| Bryant Olson | GA | Monroe Area | 2021 | LHP | 2024 | 13 | Nationals |
| Christian Oppor | WI | Columbus | 2022 | LHP | 2022 | 11 | Athletics |
| Magglio Ordonez | FL | American Heritage | 2014 | 1B | 2014 | 38 | Tigers |
| Brennan Orf | MO | Westminster Christian | 2020 | 3B | 2023 | 13 | Blue Jays |
| Demi Orimoloye | ON | St. Matthew | 2015 | OF | 2015 | 4 | Brewers |
| Robert Orloski | ID | Middleton | 2023 | RHP | 2023 | 20 | Red Sox |
| Jorel Ortega | FL | Spanish River Community | 2019 | SS | 2022 | 6 | Twins |
| D'Angelo Ortiz | FL | Westminster Christian | 2022 | 3B | 2024 | 19 | Red Sox |
| JeanPierre Ortiz | FL | IMG Academy | 2022 | SS | 2022 | 20 | Nationals |
| Deniel Ortiz | GA | Redan | 2022 | SS | 2024 | 16 | Cardinals |
| Braden Osbolt | GA | Pike County | 2022 | RHP | 2025 | 6 | Cincinnati Reds |
| Fran Oschell | PA | Malvern Prep | 2021 | RHP | 2024 | 12 | Angels |
| Ryan Osinski | VA | St. Stephens & St. Agnes | 2022 | RHP | 2025 | 17 | New York Yankees |
| Graham Osman | CO | Colorado Academy | 2019 | LHP | 2023 | 10 | Reds |
| Bryce Osmond | OK | Jenks | 2019 | RHP | 2022 | 15 | Angels |
| Kyle Ostrowski | IL | Lincoln-Way North | 2015 | LHP | 2015 | 34 | Mariners |
| Travis Ott | PA | Shippensburg Area | 2013 | LHP | 2013 | 25 | Nationals |
| Micah Ottenbreit | MI | Trenton | 2021 | RHP | 2021 | 4 | Philladelphia Phillies |
| Daniel Ouderkirk | VA | Spotswood | 2018 | RHP | 2023 | 18 | Mariners |
| Austin Overn | CA | Foothill | 2022 | OF | 2024 | 3 | Orioles |
| Hunter Owen | ME | South Portland | 2020 | LHP | 2023 | 4 | Royals |
| Tyler Owens | FL | Trinity Catholic | 2019 | RHP | 2019 | 13th | Atlanta Braves |
| Braylon Owens | TX | Elgin | 2021 | C | 2025 | 10 | Milwaukee Brewers |
| Josh Owens | TN | Providence Academy | 2025 | SS | 2025 | 3 | Texas Rangers |
| Avery Owusu-Asiedu | WI | Waukesha West | 2020 | OF | 2023 | 9 | Phillies |
| Gregory Pace Jr | MI | Detroit Edison Public School Academy | 2022 | OF | 2022 | 20 | Blue Jays |
| Christopher Paciolla | CA | Temecula Valley | 2022 | SS | 2022 | 3 | Cubs |
| Bryant Packard | NC | DH Conley | 2016 | OF | 2019 | 5 | Detroit Tigers |
| Jared Padgett | FL | Graceville | 2015 | LHP | 2015 | 26 | Cubs |
| Charlie Pagliarini | CT | St. Joseph | 2019 | 3B | 2023 | 19 | Mariners |
| Trey Paige | PA | Exeter Township | 2019 | 3B | 2023 | 17 | Cardinals |
| Andrew Painter | FL | Calvary Christian Academy | 2021 | RHP | 2021 | 1 | Philadelphia Phillies |
| Richie Palacios | NY | Berkely Carroll | 2015 | SS | 2018 | 3 | Cleveland Indians |
| Davis Palermo | NC | Northwood | 2018 | RHP | 2022 | 8 | Rockies |
| Bryan Pall | IL | Sandburg | 2014 | RHP | 2017 | 25 | Mariners |
| Peyton Pallette | AR | Benton | 2019 | RHP | 2022 | 2 | White Sox |
| Damiano Palmegiani | BC | Vauxhall Academy | 2018 | 3B | 2021 | 14 | Toronto Blue Jays |
| Trent Palmer | MN | Anoka | 2017 | RHP | 2020 | 3rd | Toronto Blue Jays |
| Jaylen Palmer | NY | Holy Cross | 2018 | SS | 2018 | 22 | New York Mets |
| Twine Palmer | OK | Kiowa | 2023 | RHP | 2024 | 19 | Astros |
| Dylan Palmer | NJ | Notre Dame | 2022 | 2B | 2025 | 11 | Pittsburgh Pirates |
| Laif Palmer | CO | Golden | 2023 | RHP | 2023 | 20 | Rangers |
| Noah Palmese | FL | Seminole | 2021 | RHP | 2025 | 14 | Toronto Blue Jays |
| Carson Palmquist | FL | Riverdale | 2019 | LHP | 2022 | 3 | Rockies |
| Alex Pantuso | PA | Baldwin | 2014 | RHP | 2018 | 31 | Athletics |
| Shane Panzini | NJ | Red Bank Catholic | 2021 | RHP | 2021 | 4 | Kansas City Royals |
| Michael Papierski | IL | Lemont | 2014 | C | 2017 | 9 | Astros |
| Kevin Parada | CA | Loyola | 2020 | C | 2022 | 1 | Mets |
| Kyren Paris | CA | Freedom | 2019 | SS | 2019 | 2nd | Angels |
| Trendan Parish | TX | Southwest Christian | 2021 | SS | 2025 | 10 | Tampa Bay Rays |
| Eddie Park | CA | Valley Christian | 2020 | OF | 2023 | 8 | White Sox |
| Aaron Parker | CA | Los Altos | 2021 | C | 2024 | 6 | Blue Jays |
| Jason Parker | NC | West Craven | 2016 | RHP | 2019 | 16 | Cincinnati Reds |
| Samuel Parker | GA | Kennesaw Mountain | 2023 | OF | 2023 | 19 | Twins |
| Caedmon Parker | TX | The Woodlands Christian | 2021 | RHP | 2025 | 15 | Chicago White Sox |
| Joseph Parker | MS | Purvis | 2025 | SS | 2025 | 2025 | Toronto Blue Jays |
| Jacob Parker | MS | Purvis | 2025 | OF | 2025 | 19 | Arizona Diamondbacks |
| Erik Parker | GA | North Gwinnett | 2024 | SS | 2024 | 15 | Dodgers |
| Wyatt Parliament | NY | LaFargeville | 2022 | RHP | 2024 | 7 | Yankees |
| Jordan Parr | IL | Illinois Valley Central | 2009 | 3B | 2013 | 15 | Diamondbacks |
| Justin Parr | IL | Illinois Valley Central | 2009 | OF | 2013 | 8 | Phillies |
| Jeffrey Parra | NY | Ramapo | 2016 | C | 2016 | 24 | Giants |
| Franklin Parra | NY | Copiague | 2018 | LHP | 2018 | 11 | New York Mets |
| Hunter Parsons | MD | Parkside | 2015 | RHP | 2015 | 40 | Indians |
| Mike Pascoe | NY | Arlington | 2016 | RHP | 2018 | 24th | Toronto Blue Jays |
| Paulshawn Pasqualotto | NV | Palo Verde | 2020 | RHP | 2023 | 12 | Twins |
| Vinnie Pasquantino | VA | James River (Midlothian) | 2016 | 1B | 2019 | 11th | Royals |
| Sterling Patick | CA | South Hills | 2023 | LHP | 2023 | 18 | Dodgers |
| Andrew Patrick | OH | Hilliard Darby | 2021 | SS | 2024 | 17 | Pirates |
| Chad Patrick | IN | Hebron | 2017 | RHP | 0 | 4 | Diamondbacks |
| Nick Patten | PA | IMG Academy | 2015 | 3B | 2018 | 28 | Pirates |
| Cole Patten | NJ | Sparta | 2018 | RHP | 2022 | 17 | Tigers |
| Hunter Patteson | FL | Vero Beach | 2019 | LHP | 2022 | 5 | Royals |
| Myles Patton | CA | Millikan | 2022 | LHP | 2025 | 7 | Boston Red Sox |
| Graham Pauley | GA | Milton | 2019 | 3B | 2022 | 13 | Padres |
| Truman Pauley | CA | Windward | 2023 | RHP | 2025 | 12 | New York Mets |
| Leon Paulino | FL | Elite Squad Academy | 2019 | OF | 2019 | 23rd | Boston Red Sox |
| Justin Paulsen | MO | Christian Brothers College | 2013 | 1B | 2017 | 39 | Padres |
| Nate Payne | PA | Central Dauphin | 2024 | LHP | 2024 | 18 | Marlins |
| Landen Payne | MS | St.Martin | 2021 | RHP | 2025 | 18 | Chicago White Sox |
| Braylon Payne | TX | Elkins | 2024 | OF | 2024 | 1 | Brewers |
| Mark Payton | IL | St. Rita | 2010 | OF | 2013 | 16 | Indians |