Player Draft
| Name | State | School | Class | Pos. | Year | Round | Team |
| Hayden Snelsire | MD | Stephen Decatur | 2019 | RHP | 2023 | 17 | Rays |
| DJ Snelton | IL | Lakes | 2010 | LHP | 2013 | 9 | Giants |
| Eric Snow | GA | Mary Persons | 2022 | SS | 2025 | 6 | Toronto Blue Jays |
| Michael Snyder | CA | Harvard Westlake | 2019 | 3B | 2024 | 10 | Marlins |
| Trey Snyder | MO | Liberty North | 2024 | SS | 2024 | 5 | Mets |
| Tyler Soderstrom | CA | Turlock | 2020 | C | 2020 | 1 | Oakland |
| Nick Solak | IL | Naperville North | 2013 | SS | 2016 | 2 | Yankees |
| AJ Soldra | CT | Cheshire Academy | 2023 | OF | 2025 | 16 | Los Angeles Dodgers |
| Noah Soles | NC | Ledford | 2019 | OF | 2019 | 19 | Arizona Diamondbacks |
| Anthony Solometo | NJ | Bishop Eustace | 2021 | LHP | 2021 | 2 Pick 37 | Pittsburgh Pirates |
| Jared Solomon | PA | Millville | 2015 | RHP | 2017 | 11 | Reds |
| Tommy Sommer | IN | Carmel | 2017 | LHP | 2021 | 10 | White Sox |
| Jake Sommers | WI | Hortonville | 2015 | RHP | 2019 | 10 | Cardinals |
| Drew Sommers | CA | Carlsbad | 2019 | LHP | 2022 | 11 | Rays |
| Logan Soole | CO | Monarch | 2015 | LHP | 2015 | 23 | Diamondbacks |
| Zack Soria | IL | St. Rita | 2012 | C | 2017 | 18 | Braves |
| Gustavo Sosa | NY | Tottenville | 2019 | C | 2022 | 10 | Phillies |
| Charlee Soto | FL | Reborn Christian Academy | 2023 | RHP | 2023 | 1-A | Twins |
| Jared Southard | TX | Rouse | 2019 | RHP | 2022 | 12 | Angels |
| Ty Southisene | NV | Basic | 2024 | SS | 2024 | 4 | Cubs |
| Tate Southisene | NV | Basic Academy | 2025 | SS | 2025 | 1 | Atlanta Braves |
| Logan Sowers | IN | McCutcheon | 2014 | OF | 2018 | 28 | White Sox |
| Garrett Spain | TN | Clarksville | 2018 | OF | 2021 | 15 | Blue Jays |
| Chad Spanberger | IL | Granite City | 2014 | C | 2017 | 6 | Rockies |
| Nolan Sparks | WA | Kentridge | 2020 | OF | 2024 | 13 | Cardinals |
| Zach Spears | IN | Mt. Vernon | 2015 | LHP | 2018 | 8 | Pirates |
| Tommy Specht | IA | Wahlert Catholic | 2022 | OF | 2022 | 6 | Rangers |
| Joey Spence | WI | West Bend East | 2021 | C | 2021 | 18 | Arizona Diamondbacks |
| Connor Spencer | MS | Hernando | 2019 | OF | 2025 | 12 | Chicago Cubs |
| Jared Spencer | MI | Centreville | 2021 | LHP | 2025 | 11 | Toronto Blue Jays |
| John Spikerman | TX | Lake Creek (Montgomery) | 2021 | SS | 2024 | 3 | Phillies |
| Ryan Spikes | GA | Parkview | 2021 | SS | 2021 | 3rd | Tampa Bay Rays |
| Bren Spillane | IL | Wheeling | 2015 | 1B | 2018 | 3 | Reds |
| Ben Spitznagel | OH | Colerain | 2013 | OF | 2017 | 27 | Athletics |
| Shea Sprague | MA | Boston College | 2021 | LHP | 2024 | 13 | Red Sox |
| Jared Sprague-Lott | PA | Springside Chestnut Hill | 2020 | SS | 2024 | 9 | Athletics |
| Josh Springer | CA | Corona | 2024 | C | 2024 | 12 | Rangers |
| Blair Springfield | IL | Decatur MacArthur | 2009 | SS | 2009 | 7 | Cubs |
| Jordan Sprinkle | CA | Palm Desert | 2019 | SS | 2022 | 4 | White Sox |
| Brandon Sproat | FL | Pace | 2019 | RHP | 2022 | 3 | Mets |
| Ryan Sprock | NJ | Seton Hall Prep | 2022 | RHP | 2025 | 8 | Minnesota Twins |
| Austin St. Laurent | NC | Western Alamance | 2020 | SS | 2024 | 14 | Mariners |
| Fitz Stadler | IL | Glenbrook South | 2015 | RHP | 2018 | 18 | Blue Jays |
| Ryan Stafford | CA | Folsom | 2021 | C | 2024 | 5 | Orioles |
| Deon Stafford Jr. | PA | Lower Dauphin | 2014 | C | 2017 | 5 | Pirates |
| Samuel Stafura | NY | Walter Panas | 2023 | SS | 2023 | 2 | Cincinnati Reds |
| Connor Staine | NJ | West Morris Central | 2019 | RHP | 2022 | 5 | Rockies |
| Carl Stajduhar | CO | Rocky Mountain | 2014 | RHP | 2014 | 27 | Braves |
| Garrett Stallings | VA | Grassfield | 2016 | RHP | 2019 | 5th | Angels |
| Mitch Stalsberg | WI | Viroqua | 2014 | LHP | 2017 | 23 | Tigers |
| Riley Stanford | GA | Buford | 2022 | RHP | 2025 | 16 | Tampa Bay Rays |
| Gage Stanifer | IN | Westfield | 2022 | RHP | 2022 | 19 | Blue Jays |
| Hunter Stanley | MS | N/A | 2016 | SS | 2021 | 11 | Indians |
| Max Stanley | CO | Douglas County | 2023 | RHP | 2023 | 20 | Rays |
| Tyler Statler | IL | Hononegah | 2019 | RHP | 2019 | 14 | Cardinals |
| Adam Stauffer | PA | Coatesville Area | 2017 | RHP | 2017 | 19 | Orioles |
| Isaac Stebens | OK | Stillwater | 2020 | RHP | 2023 | 16 | Red Sox |
| Jackson Steensma | MI | Byron Center | 2022 | RHP | 2025 | 9 | Seattle Mariners |
| Logan Steenstra | MO | Liberty | 2018 | SS | 2019 | 40 | Twins |
| Hunter Steinmetz | MO | Parkview | 2015 | OF | 2018 | 11 | Blue Jays |
| Jacob Steinmetz | NY | Hebrew Academy Five Towns and Rockaways | 2021 | RHP | 2021 | 3 | Arizona Diamondbacks |
| Anthony Stephan | NJ | Ridgewood | 2021 | SS | 2024 | 13 | Reds |
| Khal Stephen | IN | Seeger | 2021 | RHP | 2024 | 2 | Blue Jays |
| Seth Stephenson | TX | Jack C Hays | 2019 | OF | 2022 | 7 | Tigers |
| Levi Sterling | CA | Notre Dame | 2024 | RHP | 2024 | CB-A | Pirates |
| Zach Sterry | OH | Lexington | 2013 | OF | 2017 | 8 | Red Sox |
| Sammy Stevens | MI | Brother Rice | 2014 | C | 2014 | 34 | Tigers |
| Will Stevens | MO | Park Hill | 2019 | RHP | 2023 | 15 | Rays |
| Jonathan Stevens | AL | Briarwood Christian | 2023 | RHP | 2025 | 16 | Minnesota Twins |
| Jake Stevenson | MN | Waconia | 2015 | RHP | 2019 | 10 | Reds |
| Tommy Stevenson | MO | Kirkwood | 2019 | C | 2022 | 19 | Athletics |
| Owen Stevenson | CA | Sacred Heart Cathedral | 2020 | RHP | 2023 | 19 | Rays |
| Luke Stevenson | NC | Wake Forest | 2023 | C | 2025 | CB-A | Seattle Mariners |
| Brock Stewart | IL | Normal West | 2010 | RHP | 2014 | 6 | Dodgers |
| Joe Stewart | MI | Portage Central | 2016 | OF | 2022 | 9 | Angels |
| Devan (DJ) Stewart | MO | Westminster Christian | 2017 | SS | 2017 | 39 | Phillies |
| Carter Stewart | FL | Eau Gallie | 2018 | RHP | 2018 | 1st | Atlanta Braves |
| Sal Stewart | FL | Westminster Christian | 2022 | 3B | 2022 | 1C | Reds |
| Bradley Stewart | GA | West forsyth | 2026 | LHP | 2023 | 17 | Tigers |
| Bradley Stewart | FL | COOPER CITY HIGH SCHOOL | 2023 | LHP | 2023 | 17 | Tigers |
| Travis Sthele | TX | Ronald Reagan | 2020 | RHP | 2023 | 12 | Nationals |
| Griffin Stieg | VA | McLean | 2022 | RHP | 2025 | 18 | Seattle Mariners |
| Jonathan Stiever | WI | Cedarburg | 2015 | RHP | 2018 | 5 | White Sox |
| Ian Stiffler | PA | Somerset Area | 2013 | RHP | 2013 | 7 | Braves |
| Matthew Stil | NJ | Cherokee | 2018 | RHP | 2019 | 21 | Kansas City Royals |
| Doug Still | MO | Sikeston | 2014 | LHP | 2017 | 11 | Giants |
| Dillon Stiltner | GA | Trinity Christian | 2025 | RHP | 2025 | 18 | New York Mets |
| Tristan Stivors | TX | Medina Valley | 2017 | OF | 2022 | 16 | White Sox |
| Zach Stoner | IL | Rockford Boylan | 2012 | C | 2012 | 12 | White Sox |
| Justin Storm | MS | Madison Central | 2020 | LHP | 2023 | 7 | Marlins |
| Ethan Storm | IL | Sycamore | 2022 | RHP | 2025 | 13 | Tampa Bay Rays |
| Levi Stoudt | PA | Perkiomen School | 2016 | RHP | 2019 | 3 | Mariners |
| Eric Stout | IL | St. Francis | 2011 | LHP | 2014 | 13 | Royals |
| Peyton Stovall | LA | Haughton | 2021 | SS | 2024 | 4 | Reds |
| Brady Stover | IA | Collins- Maxwell-Baxter | 2016 | LHP | 2019 | 31 | Nationals |
| Josh Stowers | IL | Mount Carmel | 2015 | OF | 2018 | 2 | Mariners |
| Justin Stransky | WA | Emerald Ridge | 2021 | C | 2025 | 10 | Chicago Cubs |
| Garrett Stratton | TX | Strake Jesuit | 2022 | RHP | 2025 | 20 | New York Mets |
| Austin Strickland | OH | Moeller | 2020 | RHP | 2023 | 8 | Pirates |
| Samuel Strickland | AL | Briarwood Christian | 2017 | LHP | 2021 | 19 | Braves |