Player Draft
| Name | State | School | Class | Pos. | Year | Round | Team |
| Tommy Doyle | VA | Flint Hill | 2014 | RHP | 2017 | 2 | Rockies |
| Liam Doyle | NH | Pinkerton Academy | 2022 | LHP | 2025 | 1 | St. Louis Cardinals |
| Joel Dragoo | TX | Northside Christian Academy | 2021 | 3B | 2024 | 7 | Phillies |
| Kohl Drake | TX | Wylie | 2018 | LHP | 2022 | 11 | Pirates |
| Isaiah Drake | GA | North Atlanta | 2023 | OF | 2023 | 5 | Braves |
| Dylan Dreiling | KS | Hays | 2022 | OF | 2024 | 2 | Rangers |
| Dylan Driessen | NE | Millard West | 2022 | RHP | 2025 | 18 | St. Louis Cardinals |
| Logan Driscoll | VA | Lake Braddock | 2016 | C | 2019 | Comp B | Padres |
| Tyler Driver | NC | Pro5 Academy | 2019 | RHP | 2019 | 18 | Seattle Mariners |
| Jay Driver | MA | Wellesley | 2020 | RHP | 2023 | 9 | Guardians |
| Shane Drohan | FL | Cardinal Newman | 2017 | LHP | 2017 | 23 | Phillies |
| Jake Drossner | PA | Council Rock North | 2012 | LHP | 2015 | 10 | Brewers |
| Hunter Dryden | GA | Veterans | 2022 | OF | 2024 | 17 | Giants |
| Conor Dryer | MO | Rockwood Summit | 2017 | OF | 2021 | 17 | Rays |
| Jayden Dubanewicz | FL | Stoneman Douglas | 2024 | RHP | 2024 | 16 | Brewers |
| Cody Dube | ME | Windham | 2012 | RHP | 2016 | 10 | Orioles |
| Kevin Duchene | IL | Joliet Catholic | 2012 | LHP | 2015 | 5 | Athletics |
| Bryson Dudley | TX | Cedar Ridge | 2022 | C | 2025 | 7 | Kansas City Royals |
| Cole Duensing | KS | Blue Valley Northwest | 2016 | RHP | 2016 | 6 | Angels |
| Brandon Dufault | NH | Windham | 2017 | RHP | 2021 | 16 | Los Angeles Angels |
| Mathew Duffy | ON | Assumption | 2020 | RHP | 2023 | 4 | Red Sox |
| Dayton Dugas | LA | Sam Houston | 2015 | OF | 2018 | 16 | Tigers |
| Gavin Dugas | LA | Houma Christian | 2018 | SS | 2023 | 6 | Nationals |
| Cameron Dulle | MO | Oakville | 2014 | - | 2019 | 30 | Cardinals |
| Nicholas David Dumesnil | CA | Huntington Beach | 2022 | OF | 2025 | 8 | Detroit Tigers |
| Titus Dumitru | OR | Sam Barlow | 2021 | 1B | 2024 | 16 | Braves |
| Andrew Duncan | FL | A3 Academy | 2023 | OF | 2023 | 19 | Astros |
| Andrew Dunford | GA | Houston County | 2023 | RHP | 2023 | 12 | Detroit Tigers |
| Clay Dungan | IN | Yorktown | 2015 | SS | 2019 | 9 | Royals |
| Elijah Dunham | IN | Evansville Reitz | 2017 | OF | 2019 | 40 | Pirates |
| Hayden Dunhurst | MS | Pearl River Central | 2019 | C | 2022 | 6 | Royals |
| Blake Dunn | MI | Saugatuck | 2017 | OF | 2021 | 15 | Cincinnati Reds |
| Nick Dunn | PA | Shikellamy | 2015 | 2B | 2018 | 5 | Cardinals |
| Ross Dunn | UT | Cottonwood | 2020 | LHP | 2023 | 10 | Twins |
| Parker Dunshee | IN | Zionsville | 2013 | RHP | 2017 | 7 | Athletics |
| Antoine Duplantis | LA | Lafayette | 2015 | OF | 2019 | 12th | Mets |
| Caleb Durbin | IL | Lake Forest | 2018 | SS | 2021 | 14 | Atlanta Braves |
| Brendan Durfee | CA | St Francis | 2020 | C | 2024 | 14 | Padres |
| Hayden Durke | LA | North Vermilion | 2020 | RHP | 2023 | 13 | Diamondbacks |
| Andrew Dutkanych IV | IN | Brebeuf | 2022 | RHP | 2024 | 7 | Cardinals |
| Samuel Dutton | AL | Westbrook Christian | 2021 | RHP | 2025 | 10 | Athletics |
| Dallas Dyar | MS | Clinton | 2019 | 3B | 2019 | 21 | Phillies |
| Connor Dykstra | BC | Sardis | 2019 | C | 2024 | NDFA | Seattle Mariners |
| Joseph Dzierwa | OH | Otsego | 2022 | LHP | 2025 | 2 | Baltimore Orioles |
| Clark Eagan | WI | Appleton North | 2013 | OF | 2016 | 9 | Pirates |
| Daniel Eagen | NC | Fuquay-Varina | 2021 | RHP | 2024 | 3 | Diamondbacks |
| Jerrion Ealy | MS | Jackson Preparatory | 2019 | OF | 2019 | 31 | Diamondbacks |
| Connelly Early | VA | James River - Midlothian | 2020 | LHP | 2023 | 5 | Red Sox |
| Todd Eaton | IL | Greenville | 2010 | RHP | 2014 | 34 | Royals |
| Keenan Eaton | CO | Chaparral | 2014 | OF | 2014 | 39 | Phillies |
| Nathan Eaton | VA | Thomas Dale | 2015 | SS | 2018 | 21 | Royals |
| Konner Eaton | VA | Prince George | 2021 | LHP | 2024 | 6 | Rockies |
| Brady Ebel | CA | Corona | 2025 | SS | 2025 | 1C | Milwaukee Brewers |
| Weston Eberly | FL | Bishop Moore | 2019 | - | 2023 | 16 | White Sox |
| Blake Ebo | NJ | Trenton Catholic | 2016 | OF | 2016 | 28 | Blue Jays |
| Steven Echavarria | NJ | Millburn | 2023 | RHP | 2023 | 3 | Athletics |
| Kaden Echeman | OH | Vandalia Butler | 2021 | RHP | 2025 | 12 | St. Louis Cardinals |
| Juan Javier Echevarria | FL | Osceola | 2015 | RHP | 2015 | 21 | Orioles |
| Matt Eckelman | KS | St. James | 2012 | RHP | 2016 | 21 | Pirates |
| Noah Edders | IL | Downers Grove South | 2021 | RHP | 2025 | 15 | Chicago Cubs |
| Jake Eddington | MO | Doniphan | 2020 | RHP | 2023 | 7 | Phillies |
| Jake Eder | FL | Calvary Christian | 2017 | LHP | 2017 | 34 | Mets |
| Kamden Edge | OK | Boswell | 2023 | SS | 2025 | 20 | Kansas City Royals |
| Austin Edgette | PA | Downingtown East | 2013 | LHP | 2018 | 33 | Giants |
| Garrett Edwards | LA | Pitkin | 2020 | RHP | 2023 | 11 | Rays |
| Finn Edwards | OR | Summit | 2024 | RHP | 2025 | 18 | Los Angeles Dodgers |
| Nick Egnatuk | NJ | Immaculata | 2017 | 3B | 2017 | 5 | Milwaukee Brewers |
| Zachary Ehrhard | FL | Wharton | 2021 | OF | 2024 | 4 | Red Sox |
| Austin Ehrlicher | CA | Santa Rosa | 2021 | RHP | 2022 | 18 | Boston |
| Johnny Eierman | MO | Warsaw | 2011 | SS | 2011 | 3 | Rays |
| Jeremy Eierman | MO | Warsaw | 2015 | SS | 2018 | CBB | Athletics |
| Brandon Eike | VA | Powhatan | 2020 | 3B | 2024 | 13 | Mariners |
| Riley Eikhoff | VA | Patriot | 2020 | RHP | 2025 | 9 | Chicago White Sox |
| Josh Ekness | TX | The Woodlands | 2020 | RHP | 2023 | 12 | Marlins |
| Bryce Eldridge | VA | James Madison | 2023 | RHP | 2023 | 1 | Giants |
| Frank Elissalt | FL | Southwest Miami | 2020 | RHP | 2024 | 19 | Mets |
| Lucas Elissalt | FL | Southwest Miami Senior | 2022 | RHP | 2024 | 13 | Tigers |
| Jaron Elkins | TN | Goodpasture Christian | 2023 | OF | 2023 | 8 | Dodgers |
| Tim Elko | FL | Hillsborough | 2017 | 3B | 2022 | 10 | White Sox |
| Magnus Ellerts | VA | Woodbridge | 2019 | RHP | 2022 | 11 | Guardians |
| Hunter Elliot | MS | Tupelo | 2021 | LHP | 2024 | 20 | Dodgers |
| Clark Elliott | IL | Barrington | 2019 | OF | 2022 | CBB | Athletics |
| Evan Elliott | ON | Michael Power St. Joseph | 2019 | RHP | 2021 | 15 | Texas Rangers |
| Drew Ellis | IN | Jeffersonville | 2014 | SS | 2017 | 2 | DiamondBacks |
| James Ellwanger | TX | Magnolia West | 2023 | RHP | 2025 | 3 | Minnesota Twins |
| Austin Emener | GA | First Presbyterian Day | 2020 | LHP | 2023 | 16 | Colorado Rockies |
| Colt Emerson | OH | John Glenn | 2023 | SS | 2023 | 1 | Mariners |
| Cameron Enck | PA | Lampeter-Strasburg | 2015 | RHP | 2019 | 27 | Rockies |
| Scott Engler | KS | Bishop Carroll | 2015 | RHP | 2016 | 16 | Rangers |
| Blayne Enlow | LA | St Amant | 2017 | RHP | 2017 | 3 | Twins |
| Dietrich Enns | IL | Lincoln-Way East | 2009 | LHP | 2012 | 19 | Yankees |
| Kole Enright | FL | West Orange | 2016 | 3B | 2016 | 3 | Rangers |
| Nic Enright | VA | Steward | 2015 | RHP | 2019 | 20th | Indians |
| Sean Episcope | IL | The Latin School of Chicago | 2022 | RHP | 2025 | 5 | Milwaukee Brewers |
| Dylan Eskew | FL | Sickles | 2019 | RHP | 2019 | 24th | Arizona Diamondbacks |
| Alan Espinal | FL | Viera | 2020 | C | 2024 | 11 | Rockies |
| Edian Espinal | FL | Viera | 2022 | SS | 2025 | 10 | Detroit Tigers |
| Daniel Espino | GA | Georgia Premier Academy | 2019 | RHP | 2019 | 1st | Cleveland Indians |
| Tyler Esplin | FL | IMG Academy | 2017 | OF | 2017 | 7 | Red Sox |
| Gerardo Esquival | IL | De La Salle | 2009 | RHP | 2009 | 24 | Cubs |