Player Draft
| Name | State | School | Class | Pos. | Year | Round | Team |
| Cedric De Grandpre | QC | Academie Baseball Canada | 2020 | RHP | 2022 | 13 | Braves |
| Nander De Sedas | FL | Montverde Academy | 2018 | SS | 2018 | 29th | Milwaukee Brewers |
| Aidan Deakins | MD | Appoquinimink (DE) | 2022 | LHP | 2024 | 13 | Rangers |
| Nick Dean | PA | Bensalem | 2019 | RHP | 2023 | 19 | Cubs |
| Noah Dean | NJ | Pinelands Regional | 2019 | LHP | 2022 | 5 | Red Sox |
| Tyler Dearden | NJ | Rancocas Valley | 2017 | OF | 2017 | 29 | Boston Red Sox |
| Ryan Dease | FL | TNXL Academy | 2017 | RHP | 2017 | 4 | Rangers |
| Kyle DeBarge | LA | Barbe | 2021 | SS | 2024 | 1-C | Twins |
| Jaron DeBerry | TX | Byron Nelson | 2020 | RHP | 2024 | 3 | Brewers |
| Joe DeCarlo | PA | Garnet Valley | 2012 | 3B | 2012 | 2 | Mariners |
| Nick Decker | NJ | Seneca | 2018 | OF | 2018 | 2 | Boston Red Sox |
| Brandon Decker | MI | North Farmington | 2020 | RHP | 2024 | 19 | Yankees |
| Cameron Decker | IN | Evansville North | 2022 | 3B | 2022 | 18 | Dodgers |
| Justin DeCriscio | CA | Orange Lutheran | 2021 | SS | 2025 | 10 | San Diego Padres |
| Craig Dedelow | IN | Munster | 2013 | OF | 2017 | 9 | White Sox |
| Nick Deeg | MI | Lake Orion | 2013 | LHP | 2016 | 30 | Giants |
| Bailey Dees | NC | Hough | 2017 | RHP | 2021 | 18 | New York Yankees |
| Jaycob Deese | TX | North Shore | 2018 | RHP | 2022 | 17 | Pirates |
| Dean Deetz | MO | Nixa | 2012 | RHP | 2014 | 11 | Astros |
| Ryan Degges | TN | Christian Academy of Knoxville | 2021 | RHP | 2024 | 17 | Phillies |
| Josh Degraaf | IL | Morris | 2011 | RHP | 2015 | 31 | Blue Jays |
| Jack DeGroat | VA | Loudoun Valley | 2015 | RHP | 2018 | 11 | Indians |
| Kyle DeGroat | NY | Wallkill | 2024 | RHP | 2024 | 14 | Royals |
| Paul DeJong | IL | Antioch | 2011 | 3B | 2015 | 4 | Cardinals |
| Holden deJong | NJ | St. Augustine Prep | 2022 | LHP | 2025 | 11 | Baltimore Orioles |
| Jacob DeLabio | WI | Tremper | 2016 | RHP | 2021 | Free Agent | Houston Astros |
| Chase DeLauter | WV | Hedgesville | 2019 | OF | 2022 | 1 | Guardians |
| Jake DeLeo | CT | Avon Old Farms | 2020 | OF | 2023 | 6 | Marlins |
| Joseph Delossantos | VA | Granville Central | 2019 | OF | 2024 | 10 | Yankees |
| Dylan DeLucia | FL | New Smyrna Beach | 2019 | RHP | 2022 | 6 | Guardians |
| Cody Delvecchio | CA | Mission Hills | 2022 | OF | 2025 | 12 | San Francisco Giants |
| Carson DeMartini | VA | Ocean Lakes | 2021 | SS | 2024 | 4 | Phillies |
| Mason Denaburg | FL | Merritt Island | 2018 | RHP | 2018 | 1st | Washington Nationals |
| Matt Dennis | IL | Rolling Meadows | 2013 | RHP | 2016 | 14 | Rockies |
| Bryce Denton | TN | Ravenwood | 2015 | 3B | 2015 | 2 | Cardinals |
| Cade Denton | TX | Dallas Christian | 2020 | RHP | 2023 | 6 | Rockies |
| Jake DePew | IL | Granite City | 2010 | C | 2010 | 9 | Rays |
| Anthony DePino | CT | Daniel Hand | 2021 | 3B | 2025 | 7 | Chicago White Sox |
| Domenic DeRenzo | PA | Pittsburgh Central Catholic | 2015 | C | 2015 | 40 | Cubs |
| Nick Derr | FL | Sarasota | 2016 | SS | 2016 | 33 | Reds |
| Ryan DeSanto | MD | Tuscarora | 2022 | LHP | 2025 | 12 | Cleveland Guardians |
| Reid Detmers | IL | Glenwood | 2017 | LHP | 2017 | 32 | Braves |
| Nathan Dettmer | TX | Johnson | 2020 | RHP | 2023 | 5 | Athletics |
| Ricky DeVito | NY | St Joseph by the Sea | 2016 | RHP | 2019 | 8 | Braves |
| Nolan DeVos | NC | Hickory Ridge | 2019 | RHP | 2022 | 5 | Astros |
| Zach Dezenzo | OH | Marlington | 2018 | SS | 2022 | 12 | Astros |
| Derek Diamond | CA | Ramona | 2019 | RHP | 2022 | 5 | Pirates |
| Khadim Diaw | CA | Notre Dame | 2021 | C | 2025 | 3 | Twins |
| Davis Diaz | CA | Acalanes | 2021 | SS | 2024 | 8 | Athletics |
| Jatnk Diaz | PA | Hazleton Area High School | 2023 | 1B | 2023 | 8 | Tigers |
| Randal Diaz | PR | Leadership Christian Academy | 2021 | 2B | 2024 | 5 | Nationals |
| Jared DiCesare | VA | Chantilly | 2016 | RHP | 2019 | 17th | Blue Jays |
| Sonny DiChiara | AL | Hoover | 2018 | 1B | 2022 | 5 | Angels |
| Korbyn Dickerson | KY | Trinity | 2022 | OF | 2025 | 5 | Seattle Mariners |
| Dustin Dickerson | MS | West Jones | 2019 | 3B | 2023 | 8 | Royals |
| Blake Dickerson | VA | Ocean Lakes | 2023 | LHP | 2023 | 12 | Padres |
| Luke Dickerson | NJ | Morris Knolls | 2024 | SS | 2024 | 2 | Nationals |
| Jared Dickey | TN | Friendship Christian | 2020 | OF | 2023 | 11 | Royals |
| Daniel Dickinson | WA | Kennewick | 2022 | 2B | 2025 | 6 | Milwaukee Brewers |
| Tristan Dietrich | PA | Owen J. Roberts | 2023 | LHP | 2023 | 18 | Marlins |
| Matthias Dietz | IL | Sandburg | 2014 | RHP | 2016 | 2 | Orioles |
| Jay Dill | TN | The Baylor School | 2021 | RHP | 2025 | 18 | Athletics |
| Thomas Dillard | MS | Oxford | 2016 | OF | 2019 | 5 | Brewers |
| Mark DiLuia | IL | Marian Catholic | 2017 | RHP | 2017 | 38 | Rangers |
| Max Dineen | NJ | Pennsville | 2018 | OF | 2018 | 35 | Cincinatti Reds |
| Marco Dinges | FL | East Lake | 2021 | C | 2024 | 4 | Brewers |
| Owen Diodati | ON | A.N. Myer | 2019 | OF | 2019 | 29 | Toronto Blue Jays |
| Jordan Dissin | PA | Malvern Prep | 2020 | C | 2022 | 12 | Phillies |
| JD Dix | WI | Whitefish Bay | 2024 | SS | 2024 | CB-A | Diamondbacks |
| Jasiah Dixon | CA | Orange Lutheran | 2019 | OF | 2019 | 23 | Pirates |
| Joey Dixon | UT | Bingham | 2020 | RHP | 2023 | 7 | Astros |
| Brad Dobzanski | NJ | Delsea | 2017 | RHP | 2017 | 39 | San Francisco Giants |
| Dylan Dodd | IL | Danville | 2016 | LHP | 2021 | 3 | Atlanta Braves |
| Griffin Doersching | WI | Greendale | 2017 | 1B | 2022 | 8 | Padres |
| Marquise Doherty | MO | Winnetonka | 2015 | OF | 2015 | 15 | Royals |
| Steve Doherty | CA | Vancouver College, Canada | 1993 | SS | 1997 | 45 | Arizona Diamondbacks |
| Nate Dohm | IN | Zionsville | 2021 | RHP | 2024 | 3 | Mets |
| Chase Dollander | GA | Greenbrier | 2020 | RHP | 2023 | 1 | Rockies |
| Trey Dombroski | NJ | Wall | 2019 | LHP | 2022 | 4 | Astros |
| Michael Dominguez | FL | Jefferson | 2019 | RHP | 2019 | 15th | Toronto Blue Jays |
| Brody Donay | FL | Lakeland Christian | 2022 | OF | 2025 | 17 | Tampa Bay Rays |
| Anthony Donofrio | NY | St. Anthony's | 2018 | OF | 2024 | 10 | Mariners |
| Charlie Donovan | IL | Westmont | 2015 | SS | 2015 | 30 | Brewers |
| Joe Donovan | IL | Westmont | 2017 | C | 2017 | 33 | Cubs |
| Ethan Dorchies | IL | Cary-Grove | 2024 | RHP | 2024 | 10 | Brewers |
| Ryan Dorow | MI | South Haven High School (LC Mohr) | 2013 | SS | 2017 | 30 | Rangers |
| Nathan Dorris | IL | Marion | 2009 | LHP | 2012 | 17 | Cubs |
| Carson Dorsey | FL | J.R. Arnold | 2021 | LHP | 2024 | 7 | Orioles |
| Terence Doston | FL | Hillsborough | 2019 | OF | 2019 | 22nd | Milwaukee Brewers |
| Destin Dotson | LA | Scotlandville Magnet | 2018 | LHP | 2018 | 12th | Rangers |
| Luke Dotson | GA | Mt. Paran | 2023 | LHP | 2025 | 11 | Arizona Diamondbacks |
| Ty Doucette | NS | TNXL Academy | 2023 | 1B | 2025 | 10 | Cincinnati Reds |
| Jack Dougherty | TN | Collierville | 2020 | RHP | 2023 | 9 | Twins |
| Cade Doughty | LA | Denham Springs | 2019 | 2B | 2022 | 2C | Blue Jays |
| Braylon Doughty | CA | Chaparral | 2024 | RHP | 2024 | CB-A | Guardians |
| Kameron Douglas | GA | Woodstock | 2022 | OF | 2025 | 20 | Detroit Tigers |
| Drew Dowd | CA | Serra | 2020 | LHP | 2023 | 8 | Rays |
| Brandon Downer | CA | Santiago | 2021 | RHP | 2024 | 13 | Orioles |
| Jeter Downs | FL | Pace | 2017 | SS | 2017 | 1 | Reds |
| Brenton Doyle | VA | Kettle Run | 2016 | OF | 2019 | 4th | Rockies |